Exceptionally Stable Fluorous Emulsions for the Intravenous Delivery of Volatile General Anesthetics
نویسندگان
چکیده
منابع مشابه
Exceptionally stable fluorous emulsions for the intravenous delivery of volatile general anesthetics.
BACKGROUND IV delivery of volatile fluorinated anesthetics has a number of potential advantages when compared with the current inhalation method of administration. We reported previously that the IV delivery of sevoflurane can be achieved through an emulsion composed of a linear fluorinated diblock copolymer, a stabilizer, and the anesthetic. However, this original emulsion was subject to parti...
متن کاملFluoropolymer-based emulsions for the intravenous delivery of sevoflurane.
BACKGROUND The intravenous delivery of halogenated volatile anesthetics has been previously achieved using phospholipid-stabilized emulsions, e.g., Intralipid. However, fluorinated volatile anesthetics, such as sevoflurane, are partially fluorophilic and do not mix well with classic nonfluorinated lipids. This effect limits the maximum amount of sevoflurane that can be stably emulsified in Intr...
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Volatile anesthetics have been shown to activate various two-pore (2P) domain K(+) (K(2P)) channels such as TASK-1 and TREK-1 (TWIK-related acid-sensitive K(+) channel), and mice deficient in these channels are resistant to halothane-induced anesthesia. Here, we investigated whether K(2P) channels were also potentially important targets of intravenous anesthetics. Whole cell patch-clamp techniq...
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The molecular mechanisms of modern inhaled anesthetics are still poorly understood although they are widely used in clinical settings. Considerable evidence supports effects on membrane proteins including ligand- and voltage-gated ion channels of excitable cells. Na(+) channels are crucial to action potential initiation and propagation, and represent potential targets for volatile anesthetic ef...
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ژورنال
عنوان ژورنال: Anesthesiology
سال: 2012
ISSN: 0003-3022
DOI: 10.1097/aln.0b013e3182475d4d